According to a report from Adam Schefter of ESPN, the San Francisco 49ers have ruled out running back Isaac Guerendo and offensive tackle Trent Williams from the line up for Sunday's game against the Miami Dolphins.
Williams has been dealing with a nagging ankle injury all season. This will be the fifth game he has missed this year.
Meanwhile, Guerendo started the last two games after running backs Christian McCaffrey and Jordan Mason suffered season-ending injuries.
Jaylon Moore will start the game in place of Williams and Guerendo will be replaced by Patrick Taylor Jr.