Dosage form:Oral 300 mg scored tablet. May be swallowed whole, chewed or dissolved in the mouth and swallowed.
The active ingredients in PSORIZIDE ®ULTRA are inorganic soluble mineral salts. The exact mechanism of action is unknown; however, it is believed PSORIZIDE ®ULTRA addresses a primary genetic biochemical defect.
POTASSIUM BROMIDEdissolves and dissociates in the digestive tract into its ionic constituents. Each tablet contains approximately 15 mg bromide (calculated). Ionic bromide is rapidly and completely absorbed from the intestine and distributed almost exclusively in the extracellular fluids. 7,8Bromide is eliminated by the kidneys and the elimination half-life is 11-12 days. "Once a day" dosing will lead to a steady state concentration in about seven weeks. 7
NICKEL SULPHATEdissolves and dissociates in the digestive tract into its ionic constituents. Each tablet contains approximately 1.5 mg of ionic nickel (calculated). According to studies, 15% to 50% of ionic nickel is absorbed on a fasted stomach. 2Food markedly decreases the rate and extent of nickel absorption. 3,4Clinical studies show that serum concentrations of nickel are variable among patients after administering the same dosage. 5Peak serum nickel concentration is reached about two hours after oral administration. "Once a day" dosing leads to steady state serum concentrations in approximately one week. Nickel is in its highly stable divalent cation state and is therefore not expected to be metabolized to any significant degree in the body. Absorbed nickel is primarily excreted in the urine and elimination half-life is about 21 hours. 3,5Renal clearance is rapid and efficient, and nickel does not accumulate in the body. 6