The Kansas City Chiefs travel to Nissan Stadium this Sunday, December 21, 2025, for a 1 p.m. EST Week 16 matchup against the Tennessee Titans. This contest carries an entirely new dynamic: the season-ending ACL tear suffered by Patrick Mahomes has officially eliminated the Chiefs from the playoffs. Now the 2-12 Titans smell blood in the water against a diminished Chiefs squad led by expected starter Gardner Minshew.
Despite the immense roster change, oddsmakers still favor the Chiefs, setting the spread at -3.5 (-104) and the moneyline at -180. Predictive models give Kansas City a 64% chance of winning, but the projected final score of 20-17 highlights a close, low-scoring affair. The total is set low at 37.5 points, yet the top betting recommendation is the Over 37.5 (-110), suggesting analysts anticipate more offensive action than the current line implies.
Explore the interactive widget below to view the latest spread, total, and moneyline betting odds and probabilities for the Chiefs-Titans game at Nissan Stadium.
This prediction and best bet for Sunday's NFL matchup between the Chiefs and Titans is from Dimers.com, a leader in sports betting predictions.
Check out all the important details on today's game, as well as the best odds sourced from the top sportsbooks in the country.
Key information on the Chiefs vs. Titans matchup, including where the game is and what time it kicks off.
Odds for the key markets in the Chiefs-Titans NFL showdown.
The odds and lines presented in this article are the best available from selected sports betting sites at the time of publication and are subject to change.
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Leveraging cutting-edge data analysis and machine learning, the experts at Dimers have executed 10,000 simulations of Sunday's Chiefs vs. Titans game.
According to Dimers' highly regarded predictive analytics model, the Chiefs are more likely to beat the Titans at Nissan Stadium. This prediction is based on the model giving the Chiefs a 64% chance of winning the game.
Furthermore, Dimers predicts that the bookmakers have gotten it right and the Chiefs and Titans each have a 50% chance of covering the spread, while the over/under total of 37.5 points has a 54% chance of going over.
These predictions and probabilities are accurate at the time of publication but are subject to change.
Our top pick for the Chiefs vs. Titans Week 16 NFL matchup is to bet on Over 37.5 points (-110).
This betting advice is formulated through detailed modeling and valuable wagering intelligence, designed to deliver you the best possible plays.
Dimers' projected final score for the Kansas City vs. Tennessee game on Sunday has the Chiefs winning 20-17.
This expert prediction is based on each team's average score following 10,000 game simulations, offering a glimpse into the potential outcome.
NFL player prop picks are an exciting way to wager on Sunday's game without necessarily betting on its outcome.
This article features the most likely first and anytime touchdown scorers for the Chiefs and Titans, along with projected player stats.
Get ready for Sunday's action between the Chiefs and Titans in Week 16 of the NFL season at Nissan Stadium, which is scheduled to start at 1 p.m. EST. We emphasize that all of the NFL best bets and NFL predictions in this article are based on 10,000 data-driven simulations of the Chiefs vs. Titans game, and they are correct at the time of publishing to help you make better decisions when placing bets at online sportsbooks.
Please note that when engaging in online betting, it is important to exercise responsible gambling practices and consult trustworthy sources for accurate and up-to-date information.