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Clubroot disease, an infection caused by the obligate intracellular protist Plasmodiophora brassicae, severely damages cruciferous crops worldwide. Although resistance genes exist in Brassica genomes, their effectiveness is often limited by the evolving diversity of P. brassicae pathotypes. Broad-spectrum resistance genes are urgently needed for durable protection, but are still lacking. To fill this gap, Yupo Wu at the Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences and colleagues identified a β-1,3-GLUCAN SYNTHASE-LIKE (GSL5) gene, the inactivation of which confers broad-spectrum clubroot resistance across multiple cruciferous species.