On Monday, Dec. 9, the performer became the first out transgender woman to be nominated in a film category.
Gascón, who vies against Amy Adams (Nightbitch), Cynthia Erivo (Wicked), Mikey Madison (Anora), Demi Moore (The Substance) and Zendaya (Challengers) in the best actress in a musical or comedy category, was previously honored at the 2024 Cannes Film Festival in May, where she shared the best actress prize with costars Zoe Saldaña, Selena Gomez and Adriana Paz.
In the musical crime drama Emilia Pérez, the 52-year-old native of Spain plays Manitas, a Mexican cartel leader who hires a lawyer named Rita (fellow nominee Saldaña) to help him transition into living as a woman named Emilia Pérez. Things get even more complicated when Pèrez decides years later that she wants to reunite with the family she left behind.
Related: Emilia Pérez Review: A Crazy, Daring Tale (with Songs!) of Crime, Revenge and Gender Identity
In all, Emilia Pérez received 10 Golden Globe nominations, including best picture - musical or comedy and best director.
Audiard previously told Netflix he was inspired by Boris Razon's novel Écoute. "Halfway through the book, a transgender drug dealer comes along who wishes to have surgery," according to the director. "As the character wasn't that developed over the following chapters, I decided to start my story there."
Related: Selena Gomez, Zoe Saldaña and Karla Sofía Gascón Stun in Trailer for Spanish-Language Musical Emilia Pérez
On the red carpet of the Emilia Pérez premiere at the Toronto Film Festival in September, Gascón told PEOPLE she was touched by all the awards attention the movie was generating.
"For me, I don't know. What can I say? It is amazing for me," she said.
The Golden Globes air live on Sunday, Jan. 5, at 8 p.m. ET on CBS and Paramount+.