The association of primary sclerosing cholangitis (PSC) with paediatric-onset inflammatory bowel disease (IBD) affected the disease prognosis, with nearly a 28-fold higher risk for cancer and a 13-fold higher risk for mortality seen among children with IBD and PSC than among the general population.
"Close follow‐up to ensure early detection of both colonic and hepatic cancers seems necessary, particularly during adolescence and the transition to adulthood," the authors of the study wrote.
This study was led by Marie‐Laura Godet, Department of Pediatrics, CHU Lille, Lille, France. It was published online on August 12, 2025, in the Journal of Pediatric Gastroenterology and Nutrition.
The sample size of the cohort was relatively small, thereby affecting the analysis of treatment exposure owing to a lack of statistical power.
This study was supported by the François Aupetit Association, Programme Hospitalier de Recherche Clinique interrégional, and the Conseil Régional du Nord‐Pas‐de‐Calais (INSPIRED cohort). The registry involved in the study received financial support from the François Aupetit Association, Lille University Hospital, Amiens University Hospital, and Rouen University Hospital. The authors declared having no conflicts of interest.