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Zander Fagerson will make his first appearance in more than seven months, while captain Sione Tuipulotu is the only player to retain his place, in Scotland's starting line-up to face Tonga on Sunday.
Glasgow Warriors tighthead Fagerson has been sidelined since April through a combination of calf and knee injuries.
But he will be part of an experienced front row alongside fellow Warriors prop Rory Sutherland and Harlequins hooker George Turner, who will win his 50th cap, in Scotland's final autumn Test.
There is no place in the squad for Bath fly-half Finn Russell, joint record try-scoring wing Darcy Graham and full-back Blair Kinghorn as Gregor Townsend makes sweeping changes.